Abstract Antimicrobial resistance is a global public health concern, and livestock play a significant role in selecting for resistance and maintaining such reservoirs. Here we study the succession of dairy cattle resistome during early life using metagenomic sequencing, as well as the relationship between resistome, gut microbiota, and diet. In our dataset, the gut of [...]
Abstract The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a [...]
Testing platform will allow the research community to explore the human microbiome in new ways. The microbiome is a collection of trillions of bacteria that reside in and on our bodies. Each person’s microbiome is unique — just like a fingerprint — and researchers are finding more and more ways in which it impacts our [...]
A paper yesterday in the New England Journal of Medicine is offering new details on the two patients who developed drug-resistant bloodstream infections after undergoing fecal microbiota transplantation (FMT). The two patients, one of whom died, were first reported by the Food and Drug Administration (FDA) in a Jun 13 safety alert, in which the agency warned [...]
A global consortium that includes the Democratic Republic of the Congo (DRC) ministry of health, Doctors without Borders, the Wellcome Trust, and CEPI (the Coalition for Epidemic Preparedness Innovations), among other groups, is preparing for the introduction of a second Ebola vaccine to be used in the DRC in the coming days. And in disease [...]
Highlights Antibiotics for urinary tract indications were often not concordant to guidelines. Prophylactic urinary tract infection prescriptions were infrequently reviewed. Only 10.4% of cefalexin prescriptions for cystitis were concordant to guidelines. Additional daily doses of cefalexin were common in cystitis treatment. Image by Ewa Urban from Pixabay Read more… The post Urinary tract infections [...]
The brain waves generated during deep sleep appear to trigger a cleaning system in the brain that protects it against Alzheimer’s and other neurodegenerative diseases. Electrical signals known as slow waves appear just before a pulse of fluid washes through the brain, presumably removing toxins associated with Alzheimer’s, researchers reported Thursday in the journal Science. Read and listen [...]
Abstract Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, [...]
GENEVA — Walk into Mike Ryan’s office here on the orderly campus of the World Health Organization and you are in a train station. Staff members rush in to see the agency’s ruddy, fast-talking emergencies chief to seek guidance on the various disease outbreaks they are trying to end. People crowd into the office where a [...]
Asthma–COPD overlap (ACO) has recently been recognised as a separate phenotype of obstructive airway diseases and is included in several guidelines of asthma and COPD [1–5]. ACO patients have previously been shown to have lower diffusing capacity of the lung, higher blood neutrophil counts and higher interleukin-6 levels compared with asthma patients [6]. In COPD, [...]
